Oral Fucoidan Attenuates Lung Pathology and Clinical Signs in a Severe Influenza A Mouse Model

Oral Fucoidan Attenuates Lung Pathology and Clinical Signs in a Severe Influenza A Mouse Model

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Fucoidans are known to be effective inhibitors of inflammation, and of virus binding and cellular entry.Undaria pinnatifida-derived fucoidan (UPF) was assessed in a severe influenza A (H1N1, PR8) infection model in mice.Initially, UPF was gavaged at 3.52 mg daily in a treatment model.Gross lung pathology kaiser copy stands (consolidation) was significantly reduced as compared to controls.

UPF was then presented as a feed supplement at a rate replica beach walk candle of either nil, 3.52 mg/day or 7.04 mg/day in a prophylactic model, dosed three days before infection.A significant improvement was observed in the clinical signs of ill-health, as well as a reduction in gross lung pathology in animals treated with the higher dose, although there was no significant reduction in lung viral titres.